Hematology and Cell Therapy

Thrombosis and Coagulation

Coagulation mechanism involves in stopping the flow of blood due to an injured or defective vessel wall. The change within the blood into an insoluble gel when injured is blood coagulation. The Coagulation factors are characterized by procoagulatory and anticoagulatory which are in balanced state under normal conditions. The fibrinolytic system prevents the blood clots being problematic for the blood components and this process requires phospholipids, calcium and coagulation factors. Thrombosis summarizes as a variation in the clotting capacity of the blood which partially or entirely stops the flow of blood through that vein. Complications of thrombosis can be life-threatening to a person. When blood clots blocks while blood flows through the veins leads to venous thrombosis. Arterial thrombosis is when the blood clot blocks an artery while oxygen-rich blood carried from heart to the body.

Treatment may include-

• Anticoagulants
• Thin tubes and stent helps to open the blocked vessels
• Medicines to prevent clots